Ozempic: It is not without some risks

It is used my MANY, and for good reason- it helps people reverse obesity and other medical conditions but is it really as miraculous as they make it out to be?

Let’s talk about this more.

Ozempic is a brand name for semaglutide, a medication in the class of glucagon-like peptide-1 (GLP-1) receptor agonists. Initially developed to treat type 2 diabetes by improving blood sugar regulation, Ozempic has gained widespread recognition for its efficacy in promoting significant weight loss. The drug mimics the effects of the GLP-1 hormone, which reduces appetite, slows gastric emptying, and enhances insulin secretion. Other GLP-1 Receptor Agonists include:

• Wegovy (also semaglutide, but approved specifically for chronic weight management)

• Saxenda (liraglutide, used for weight loss)

• Rybelsus (oral semaglutide for diabetes management)

Why is Ozempic So Popular?

Ozempic's popularity stems from its dual benefits: helping manage blood sugar levels in people with type 2 diabetes and driving significant weight loss in people with obesity or overweight conditions. It's often praised for:

1. Rapid weight loss: Patients can lose 15% or more of their body weight over time.

2. Appetite suppression: Ozempic reduces hunger, making calorie restriction more manageable.

3. Improved health markers: It can lower blood pressure, improve cholesterol levels, and reduce the risk of cardiovascular events.

Ozempic's role in weight management has catapulted it into the spotlight, often referred to as a "game-changer" for obesity treatment. It has also become popular among individuals without diabetes who seek rapid weight loss, sparking debates about its ethical use.

The Downsides and Cautions of Ozempic

While Ozempic offers undeniable benefits, there are significant downsides and risks associated with its use, especially for weight loss.

1. Muscle Loss with Rapid Weight Loss

   • Issue: Research has highlighted that rapid weight loss with GLP-1 drugs like Ozempic can lead to a greater proportion of muscle mass loss compared to slower weight loss methods.

   • Muscle Mass Concerns: Skeletal muscles play a dual role:

     • Structural and functional: They enable physical movement, balance, and strength.

     • Metabolic: They act as reservoirs for amino acids, regulate blood glucose, and support immune function.

   • Study Findings: A commentary published in The Lancet showed that muscle loss from GLP-1 receptor agonists can constitute 25–39% of total weight lost, much higher than the 10–30% typically seen with calorie restriction alone. This rapid loss of muscle mass could:

     • Decrease immunity.

     • Increase risks of infections and poor wound healing.

     • Impair physical function and quality of life.

     • Shorten life expectancy.

   • Solution: Experts recommend pairing GLP-1 drugs with adequate protein intake and resistance exercises to preserve muscle mass.

2. Gastrointestinal Side Effects

   • Nausea, vomiting, diarrhea, and constipation are common, especially during dose escalation. We see a drastic change in the existing microbiome with Ozempic use thus may be part of the reason for all of the digestive symptoms. When there is a great alteration in the microbial balance, we also see increased rates of anxiety, depression, sleep changes, and mood irritability.

3. Potential Nutritional Deficiencies

   • Reduced appetite can lead to inadequate dietary intake, resulting in deficiencies in vitamins, minerals, and protein so when you eat, eat wisely. Choose whole foods that are more nutrient dense and contain more vitamins and minerals.

4. Gallbladder and Pancreatic Risks: GLP-1 drugs are associated with an increased risk of gallstones, pancreatitis, and potentially thyroid tumors.

5. High Cost: Ozempic is expensive, often costing several hundred dollars per month, and insurance coverage may be limited for non-diabetic uses.

6. Unknown Long-Term Effects: Since these drugs are relatively new, the long-term health implications of sustained use are not yet fully understood.

7. Ethical Concerns: The rising off-label use of Ozempic for weight loss in people without obesity has led to shortages for diabetics who rely on it for blood sugar management.

The Holistic Approach to Managing Weight Loss during Ozempic use

Given the potential downsides of Ozempic, here is an overview of things that need to be considered when on Ozempic:

• Exercise is a MUST!! Resistance training and physical activity to counteract muscle loss. A tailored exercise plan is required to ensure muscle wasting is not an issue because if you do have a weight training/exercise plan at present, what do you think will happen when you stop using Ozempic?

• Dietary Support: Adequate protein intake and a balanced diet to prevent deficiencies.

• Monitoring: Regular health checks to ensure weight loss doesn't compromise overall health. Having expanded routine labs with comprehensive thyroid checked at least every 3 months during medication use is essential to ensure no organs are being damaged or affected during use.

• Specialty testing: I would recommend performing urinary metal and mineral testing as well during Ozempic use to ensure there is adequate amounts in your body.

• Supplementation: In conjuction with any deficiencies, you can start with a general multivitamin, liver support, digestive enzymes, and probiotics

Final Thoughts

Ozempic represents a groundbreaking tool for weight management and diabetes control, but its use is not without risks. A thoughtful, balanced approach that includes dietary support, exercise, and medical oversight is essential for those considering or using Ozempic.

If you're contemplating Ozempic for weight loss or diabetes, consult a healthcare professional to weigh its benefits against potential risks and ensure a personalized treatment plan.

While I am not a prescribing physician where I practice medicine and do not prescribe GLP-1 receptor agonist drugs, I can help you on your journey if you choose to take this medication so you have the BEST results you are looking for.

Knowledge is power,

Dr. Meg

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Disclaimer: The information provided on this blog is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The content shared here is not meant to replace or supersede the guidance or recommendations of your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your diet, exercise routine, supplement regimen, or overall health plan. Your health and well-being are unique, and decisions regarding your care should always be made in consultation with your trusted healthcare provider.